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  1. Asthma is a chronic inflammatory disease characterized by airway remodeling and immune dysregulation. This study aimed to explore the mechanisms by which M2 macrophage-derived exosomes (M2Φ-Exos) regulate airw...

    Authors: Yinying Ren, Mi Zhou, Yuehan Li, Yan Li, JinYing Xiang, Fang Deng, Zhengxiu Luo, Enmei Liu, Jinyue Yu, Zhou Fu, Fengxia Ding and Bo Liu
    Citation: Journal of Inflammation 2025 22:19
    Content type: Research Published on:

  2. Autoimmune diseases (AIDs) are marked by systemic inflammation and immune dysregulation, yet current therapies often fail to target their underlying causes. Emerging evidence positions exosomal non-coding RNAs...

    Authors: Mohamed J. Saadh, Omer Qutaiba B. Allela, Ali Fawzi Al-Hussainy, Lalji Baldaniya, M. M. Rekha, Deepak Nathiya, Parjinder Kaur, Zafar Aminov, Hayder Naji Sameer, Huda Ghassan Hameed, Zainab H. Athab and Mohaned Adil
    Citation: Journal of Inflammation 2025 22:18
    Content type: Review Published on:

  3. Allergic diseases significantly impact the quality of life of people around the world. Cytokines play a crucial role in regulating the immune system. Due to their importance in pro-inflammatory mechanisms, cyt...

    Authors: Mohammad Chand Jamali, Asma’a H. Mohamed, Azfar Jamal, Mohammad Azhar Kamal, Waleed Al Abdulmonem, Bashar Abdullah Saeed, Nasrin Mansuri, Fuzail Ahmad, Mustafa Mudhafar, Alaa Shafie and Haroonrashid M. Hattiwale
    Citation: Journal of Inflammation 2025 22:17
    Content type: Review Published on:

  4. Inflammation is a key driver of disease-related malnutrition and patients with high inflammation may not show the same benefits from nutritional therapy as other patients. We compared in an exploratory manner ...

    Authors: Carla Wunderle, Elisabeth Martin, Alma Wittig, Pascal Tribolet, Thomas A. Lutz, Christina Köster-Hegmann, Zeno Stanga, Beat Mueller and Philipp Schuetz
    Citation: Journal of Inflammation 2025 22:16
    Content type: Research Published on:

  5. Several studies have demonstrated that the pulmonary immune response is primarily facilitated by antigen-presenting cells (APCs), and that both professional and non-professional APCs contribute to overall pulm...

    Authors: Yangqi Liu, Zijian Chen, Hanchang Cheng, Runzhi Zheng and Weizhe Huang
    Citation: Journal of Inflammation 2025 22:15
    Content type: Review Published on:

  6. Malvidin (MV), an essential anthocyanin, has antioxidant and anti-inflammatory effects that may help treat pulmonary fibrosis (PF), a progressive and occasionally fatal condition characterized by severe lung s...

    Authors: Dingzi Zhou, Lin Cai, Jie Xu, Daigang Fu, Ling Yan and Linshen Xie
    Citation: Journal of Inflammation 2025 22:14
    Content type: Research Published on:

  7. Acetaminophen (APAP) induced acute liver injury (ALI), the leading cause acute liver failure in the western world, has limited treatment options. APAP toxicity results in massive hepatic necrosis and secondary...

    Authors: Eilidh J. Livingstone, Jennifer A. Cartwright, Lara Campana, Philip J. Starkey Lewis, Benjamin J. Dwyer, Rhona Aird, Tak Yung Man, Matthieu Vermeren, Adriano Giorgio Rossi, Luke Boulter and Stuart John Forbes
    Citation: Journal of Inflammation 2025 22:13
    Content type: Research Published on:

  8. Microvascular injury in patients with ST-segment elevation myocardial infarction (STEMI) occurs in up to 50%, yet no therapeutic target exists. Inflammation contributes directly to myocardial damage in STEMI a...

    Authors: Jasmine Melissa Marquard, Jacob Lønborg, Laust Emil Roelsgaard Obling, Rasmus Paulin Beske, Yan Zhou, Lars Nepper-Christensen, Niels Vejlstrup, Lia Evi Bang, Christian Hassager, Fredrik Folke, Lars Bredevang Andersen, Helle Collatz Christensen, Lene Holmvang, Frants Pedersen, Ole Ahlehoff, Reza Jabbari…
    Citation: Journal of Inflammation 2025 22:12
    Content type: Research Published on:

  9. Neuroinflammation is a prominent pathological hallmark of traumatic brain injury (TBI) and glia cells have been widely characterized in the onset or progression of brain inflammation. While an effect of inflam...

    Authors: Arianna Cembran, Maxwell Eisenbaum, Daniel Paris, Michael Mullan, Fiona Crawford, Scott Ferguson and Corbin Bachmeier
    Citation: Journal of Inflammation 2025 22:11
    Content type: Research Published on:

  11. This study aimed to investigate the involvement of angiopoietin (Ang)/Tie2 pathway in mediating pulmonary endothelial glycocalyx injury in histone-induced acute lung injury in mice, and the protective mechanis...

    Authors: Jia Yin, Yawen Chi, Danyan Liu, Xinghua Li and Xu Li
    Citation: Journal of Inflammation 2025 22:9
    Content type: Research Published on:

  13. COPD has many hallmarks of autoimmune dysfunction. Driving this autoimmune response are self-antigens, such as highly abundant structural proteins and cellular proteins, which can lead to the production of aut...

    Authors: L. Heinemann, I. Adcock, K. F Chung, W. Lollinga, M. N. Hylkema, A. Papi, G. Caramori and P. A. Kirkham
    Citation: Journal of Inflammation 2025 22:7
    Content type: Research Published on:

  14. Damage to the retinal vasculature is a major cause of vision loss and is influenced by a pro-inflammatory environment within retinal tissue. Alpha-1 antitrypsin (AAT) is a potent inhibitor of serine proteases ...

    Authors: Varaporn Suphapimol, Yu-Han Liu, Sandro Prato, Alexander Karnowski, Charles Hardy, Adriana Baz Morelli, Abhirup Jayasimhan, Devy Deliyanti and Jennifer L. Wilkinson-Berka
    Citation: Journal of Inflammation 2025 22:6
    Content type: Research Published on:

  15. Subretinal injections provide direct access to photoreceptors and RPE, which is crucial for the delivery of gene therapy and neuroprotective approaches. To access the subretinal space, transvitreal (TV) and tr...

    Authors: Daniel E. Maidana, Sara Pastor Puente, Catherine Wang, Shivam Chandra, Lucia Gonzalez-Buendia, Eleftherios Paschalis Ilios, Andrius Kazlauskas and Demetrios G. Vavvas
    Citation: Journal of Inflammation 2025 22:5
    Content type: Research Published on:

  16. Sepsis is a severe condition causing organ failure due to an abnormal immune reaction to infection, characterized by ongoing excessive inflammation and immune system issues. Osteopontin (OPN) is secreted by va...

    Authors: Qian Wang, Zhicai Yu, Zhixin Song, Xue Lu, Zhu Li, Dandan Pi, Jing Li and Feng Xu
    Citation: Journal of Inflammation 2025 22:4
    Content type: Research Published on:

  17. Clostridioides difficile, a spore-forming anaerobic bacterium, is the primary cause of hospital antibiotic-associated diarrhea. Key virulence factors, toxins A (TcdA) and B (TcdB), significantly contribute to C. ...

    Authors: Dvison de Melo Pacífico, Deiziane Viana da Silva Costa, Maria Lucianny Lima Barbosa, Conceição Silva Martins Rebouças, Simone de Goes Simonato, Cirle Alcantara Warren, Maria Luana Gaudencio dos Santos Morais, Renata Ferreira de Carvalho Leitao and Gerly Anne de Castro Brito
    Citation: Journal of Inflammation 2025 22:3
    Content type: Research Published on:

  20. The chemokine CCL20, a small cytokine that belongs to the C–C chemokine family, interacts with its homologous receptor CCR6, which is expressed on wide range of cell types. According to current research, the C...

    Authors: Ya -Jing Li, Wan-Li Geng, Chen-Chen Li, Jia-Hao Wu, Fei Gao and Yong Wang
    Citation: Journal of Inflammation 2024 21:54
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Inflammation 2025 22:2

  22. Pathogenesis of atherosclerosis is largely mediated by inflammatory process. Statins are lipid-lowering drugs which also have anti-inflammatory effects. 18 fluorine radiolabeled fluorodeoxyglucose (18 F-FDG) p...

    Authors: Tannaz Jamialahmadi, Željko Reiner, Luis E. Simental-Mendia, Wael Almahmeed, Sercan Karav, Ali H. Eid, Francesco Giammarile and Amirhossein Sahebkar
    Citation: Journal of Inflammation 2024 21:52
    Content type: Research Published on:

  23. HMG-CoA reductase inhibitors are well-known medications in the treatment of cardiovascular disorders due to their pleiotropic and lipid-lowering properties. Herein, we reviewed the effects of statins on the CC...

    Authors: Hanieh Gholamalizadeh, Behzad Ensan, Sercan Karav, Tannaz Jamialahmadi and Amirhossein Sahebkar
    Citation: Journal of Inflammation 2024 21:51
    Content type: Research Published on:

  24. Polymorphonuclear neutrophils (PMN) activation by monosodium urate crystals (MSU) is crucial to acute gouty arthritis and subsequent spontaneous remission within 7–10 days. Activated PMNs release neutrophil ex...

    Authors: Cheng-Hsun Lu, Chieh-Yu Shen, Ko-Jen Li, Cheng-Han Wu, Yu-Hsuan Chen, Yu-Min Kuo, Song-Chou Hsieh and Chia-Li Yu
    Citation: Journal of Inflammation 2024 21:50
    Content type: Research Published on:

  25. Inflammation can be an unwanted consequence or cause of debilitating diseases of infectious and non-infectious aetiologies. Current anti-inflammatory medications have several deficiencies including lack of spe...

    Authors: Jonathan McGahon, Stuart Woods, Riccardo D’Elia and Craig W. Roberts
    Citation: Journal of Inflammation 2024 21:49
    Content type: Research Published on:

  27. Sepsis-induced myocardial dysfunction (SIMD) may contribute to the poor prognosis of septic patients. Carvacrol (2-methyl-5-isopropyl phenol), a phenolic monoterpene compound extracted from various aromatic pl...

    Authors: Lu Xu, Xu Yang, Xiao-Ting Liu, Xia-Yun Li, Han-Zhao Zhu, Yan-Hua Xie, Si-Wang Wang, Yao Li and Ye Zhao
    Citation: Journal of Inflammation 2024 21:47
    Content type: Research Published on:

  30. Qingdai (QD), derived from various plant sources, is commonly used in traditional Chinese medicine for ulcerative colitis (UC) treatment. However, the clinical efficacy and mechanisms of orally administered QD...

    Authors: Sizhen Gu, Yan Xue, Xiaowen Liu, Yini Tang, Dong Wang, Dongmei Wu, Mingrong Yao, Zehua Xia, Sen Yang, Gan Cai, Shigui Xue and Danbo Dou
    Citation: Journal of Inflammation 2024 21:44
    Content type: Research Published on:

  31. Viral infections in humans often cause excessive inflammation. In some viral infections, inflammation can be serious and even fatal, while in other infections it can promote viral clearance. Viruses can escape...

    Authors: Hossein Bannazadeh Baghi, Mobina Bayat, Parisa Mehrasa, Seyed Mohammad Amin Alavi, Mohammad Hassan Lotfalizadeh, Mohammad Yousef Memar, Seyed Pouya Taghavi, Fatemeh Zarepour, Michael R. Hamblin, Javid Sadri Nahand, Seyed Mohammad Reza Hashemian and Hamed Mirzaei
    Citation: Journal of Inflammation 2024 21:43
    Content type: Review Published on:

  32. Air pollution, notably particulate matter (PM), significantly impacts chronic respiratory disease such chronic obstructive pulmonary disease (COPD). Although asthma-COPD overlap (ACO), considered one of the CO...

    Authors: Jung Hur, Chin Kook Rhee, Hyoung Kyu Yoon, Chan Kwon Park, Jeong Uk Lim, Tai Joon An, Joon Young Choi and Yong Suk Jo
    Citation: Journal of Inflammation 2024 21:42
    Content type: Research Published on:

  33. T lymphocyte helper (Th) 2 plays the main role in pathogenesis of allergic airway diseases (AAD). Recent studies showed that interleukin (IL) 33, Th17 and Th22 also may be involved in allergic inflammation. Th...

    Authors: Laura Tamasauskiene and Brigita Gradauskiene
    Citation: Journal of Inflammation 2024 21:41
    Content type: Research Published on:

  34. Trauma and infection induce emergency granulopoiesis. Counts of immature granulocytes and transcriptional pathways of terminal granulocytic differentiation in blood are elevated in sepsis but correlate with di...

    Authors: Tobias Guenther, Anna Coulibaly, Sonia Y. Velásquez, Jutta Schulte, Tanja Fuderer, Timo Sturm, Bianka Hahn, Manfred Thiel and Holger A. Lindner
    Citation: Journal of Inflammation 2024 21:40
    Content type: Research Published on:

  35. Lipopolysaccharide (LPS) challenge in mice has been used to identify the mechanisms and therapeutics for neuroinflammation. In this study, we aimed to comprehensively evaluate the behavioral changes including ...

    Authors: Diogo Carregosa, Natasa Loncarevic-Vasiljkovic, Raquel Feliciano, Diogo Moura-Louro, César S. Mendes and Cláudia Nunes dos Santos
    Citation: Journal of Inflammation 2024 21:39
    Content type: Research Published on:

  37. The kidney is exceptionally vulnerable during sepsis, often resulting in sepsis-associated acute kidney injury (SA-AKI), a condition that not only escalates morbidity but also significantly raises sepsis-relat...

    Authors: Xinxin Li, Wei Zhou, Jianjun Chen, Liangliang Zhou, Yingbing Li, Xufeng Wu and Xia Peng
    Citation: Journal of Inflammation 2024 21:37
    Content type: Research Published on:

  38. Rheumatoid arthritis (RA) is associated with a high concentration of extracellular DNA (ecDNA). This could be a consequence of the inflammation, but the ecDNA could also be involved in the unknown etiopathogen...

    Authors: Kristína Macáková, Veronika Borbélyová, Mária Tekeľová, Jakub Janko, Michal Pastorek, Richard Hokša, Norbert Moravanský, Emöke Šteňová, Barbora Vlková and Peter Celec
    Citation: Journal of Inflammation 2024 21:36
    Content type: Research Published on:

  40. Sonic Hedgehog (Shh), extensively researched for its role in early neurogenesis and brain development, has recently been recognized for its neuroprotective potential following neuronal injuries. This study exa...

    Authors: Mohamed Tail, Hao Zhang, Guoli Zheng, Anna-Kathrin Harms, Maryam Hatami, Thomas Skutella, Karl Kiening, Andreas Unterberg, Klaus Zweckberger and Alexander Younsi
    Citation: Journal of Inflammation 2024 21:34
    Content type: Research Published on:

  41. Inflammation and neuroinflammation are integral to the progression and severity of many diseases and are strongly associated with cardiovascular disease, cancer, autoimmune disorders, neurodegenerative disease...

    Authors: Karissa Hodge, Daniel J. Buck, Subhas Das and Randall L. Davis
    Citation: Journal of Inflammation 2024 21:33
    Content type: Research Published on:

  42. Intervertebral disc degeneration (IVDD) is a common spine disease with inflammation as its main pathogenesis. Mulberroside A (MA), isolated from herbal medicine, possesses anti-inflammatory characteristics in ...

    Authors: Tao Xu, Hongqi Zhao, Xuan Fang, Shanxi Wang, Jian Li, Hua Wu, Weihua Hu and Rui Lu
    Citation: Journal of Inflammation 2024 21:32
    Content type: Research Published on:

  43. Transforming Growth Factor Beta1 (TGF-β1) signaling is upregulated in Chronic Obstructive Pulmonary disease (COPD), smokers, and people living with HIV. Cigarette smoking and HIV are also independent risk fact...

    Authors: Maria J. Santiago, Srinivasan Chinnapaiyan, Kingshuk Panda, Md. Sohanur Rahman, Suvankar Ghorai, Joseph H. Lucas, Stephen M. Black, Irfan Rahman and Hoshang J. Unwalla
    Citation: Journal of Inflammation 2024 21:31
    Content type: Research Published on:

  44. Fatigue is a common complication of stroke that has a significant impact on quality of life. The biological mechanisms that underly post-stroke fatigue are currently unclear, however, reactivation of latent vi...

    Authors: Isobel C. Mouat, Li Zhu, Alperen Aslan, Barry W. McColl, Stuart M. Allan, Craig J. Smith, Marion S. Buckwalter and Laura McCulloch
    Citation: Journal of Inflammation 2024 21:30
    Content type: Research Published on:

  45. Mice transgenic for human P301S tau protein exhibit many characteristics of the human tauopathies, including the formation of abundant hyperphoshorylated tau filaments, the associated neuroinflammation and dis...

    Authors: Ahmed Sabry Mohamed, Mahmoud ElKaffas, Karim Metwally, Mahmoud Abdelfattah, Eslam Ashraf Elsery, Ahmed Elshazly, Hossam Eldin Gomaa, Aziza Alsayed, Sara El-Desouky, Randa El-Gamal and Sara Elfarrash
    Citation: Journal of Inflammation 2024 21:29
    Content type: Research Published on:

  46. Authors: Tabata Maruyama dos Santos, Renato Fraga Righetti, Leandro do Nascimento Camargo, Edna Aparecida Leick, Silvia Fukuzaki, Elaine Cristina de Campos, Thiago Tafarel Galli, Beatriz Mangueira Saraiva-Romanholo, Luana Laura Sales da Silva, Jéssica Anastácia Silva Barbosa, Juliana Morelli Lopes Gonçalves João, Carla Máximo Prado, Bianca Goulart de Rezende, Christine Laure Marie Bourotte, Fernanda Degobbi Tenorio Quirino dos Santos Lopes, Milton de Arruda Martins…
    Citation: Journal of Inflammation 2024 21:28
    Content type: Correction Published on:

    The original article was published in Journal of Inflammation 2024 21:24

  47. We have previously discovered clusters of sequentially negative and positive modulators of acute inflammation during cytokine stimulation in epithelial cells and identified potential targets for therapy within...

    Authors: Chih-Yung Chiu, Saffron A. G. Willis-Owen, Kenny C.C. Wong, Stuart N. Farrow, William O.C. Cookson, Miriam F. Moffatt and Youming Zhang
    Citation: Journal of Inflammation 2024 21:27
    Content type: Research Published on:

  48. Atherosclerosis is a chronic inflammatory condition affecting the large arteries and is a major cause of cardiovascular diseases (CVDs) globally. Increased levels of adhesion molecules in cardiac tissue serve ...

    Authors: Mohammad Hasan Maleki, Omid Vakili, Ramin Tavakoli, Elham Nadimi, Zahra Noori, Motahareh Taghizadeh, Amirreza Dehghanian, Lobat Tayebi and Sayed Mohammad Shafiee
    Citation: Journal of Inflammation 2024 21:26
    Content type: Research Published on:

  49. Intestinal ischemia–reperfusion (I/R) injury is a severe vascular emergency. Previous research indicated the protective effects of Emodin on I/R injury. Our study aims to explore the effect of Emodin on intest...

    Authors: Yinyin Liu, Tuo Ji, Haixing Jiang, Meng Chen, Wanli Liu, Zongze Zhang and Xianghu He
    Citation: Journal of Inflammation 2024 21:25
    Content type: Research Published on:

  50. Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood.

    Authors: Tabata Maruyama dos Santos, Renato Fraga Righetti, Leandro do Nascimento Camargo, Edna Aparecida Leick, Silvia Fukuzaki, Elaine Cristina de Campos, Thiago Tafarel Galli, Beatriz Mangueira Saraiva-Romanholo, Luana Laura Sales da Silva, Jéssica Anastácia Silva Barbosa, Juliana Morelli Lopes Gonçalves João, Carla Máximo Prado, Bianca Goulart de Rezende, Christine Laure Marie Bourotte, Fernanda Degobbi Tenorio Quirino dos Santos Lopes, Milton de Arruda Martins…
    Citation: Journal of Inflammation 2024 21:24
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Inflammation 2024 21:28

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Journal of Inflammation

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