Affiliated with the British Inflammation Research Association (BIRAs).
Articles
Page 4 of 17
-
Citation: Journal of Inflammation 2021 18:30
-
Downregulation of miR-223 promotes HMGB2 expression and induces oxidative stress to activate JNK and promote autophagy in an in vitro model of acute lung injury
Excessive autophagic activity in alveolar epithelial cells is one of the main causes of acute lung injury (ALI), but the underlying molecular mechanism has not been fully elucidated. Previous studies have show...
Citation: Journal of Inflammation 2021 18:29 -
TGF-β gene polimorphisms as risk factors for asthma control among clinic patients
TGF-β and its receptors play a crucial role in asthma pathogenesis, bronchial hyperreactivity, and bronchial remodeling. Expression of isoforms 1–3 of TGFβ cytokine is influenced by tagging polymorphisms in th...
Citation: Journal of Inflammation 2021 18:28 -
Downregulation of lncRNA-PVT1 participates in the development of progressive chronic kidney disease among patients with congestive heart failure
Congestive heart failure (CHF) is a major cause of the development of progressive chronic kidney disease (CKD), while the mechanism is still unknown. LncRNA PVT1 contributes to kidney injury. This study aimed ...
Citation: Journal of Inflammation 2021 18:27 -
Therapeutic potential of a novel semi-synthetic-sulfated-polysaccharide to suppress inflammatory mediators in P. gingivalis LPS stimulated human monocytes/macrophages
Chronic periodontitis is associated with an increased risk for systemic conditions such as cardiovascular disease, diabetes, and osteoporosis. During chronic periodontitis, endotoxin (lipopolysaccharide, LPS) ...
Citation: Journal of Inflammation 2021 18:26 -
USP10 alleviates sepsis-induced acute kidney injury by regulating Sirt6-mediated Nrf2/ARE signaling pathway
Severe sepsis, a major health problem worldwide, has become one of the leading causes of death in ICU patients. Further study on the pathogenesis and treatment of acute kidney injury (AKI) is of great signific...
Citation: Journal of Inflammation 2021 18:25 -
Increased levels of S100A8/A9, IL-1ß and IL-18 as a novel biomarker for recurrent tonsillitis
Acute tonsillitis represents one of the most frequent reasons patients seek primary medical care and otorhinolaryngology consultation. Therefore, recurrent episodes of acute tonsillitis (RAT), also called chro...
Citation: Journal of Inflammation 2021 18:24 -
Bullatacin triggers immunogenic cell death of colon cancer cells by activating endoplasmic reticulum chaperones
It is well accepted that the immune system efficiently contributes to positive outcomes of chemotherapeutic cancer treatment by activating immunogenic cell death (ICD). However, only a limited number of ICD-in...
Citation: Journal of Inflammation 2021 18:23 -
The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain
Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding domain. TTP is phosphorylated extensively in cells, and its mRNA destabil...
Citation: Journal of Inflammation 2021 18:22 -
Luteolin transforms the polarity of bone marrow-derived macrophages to regulate the cytokine storm
Macrophages are indispensable regulators of inflammatory responses. Macrophage polarisation and their secreted inflammatory factors have an association with the outcome of inflammation. Luteolin, a flavonoid a...
Citation: Journal of Inflammation 2021 18:21 -
Dexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1/miR-194/SIRT1 signaling pathway
Liver injury seriously threatens the health of people. Meanwhile, dexmedetomidine hydrochloride (DEX) can protect against liver injury. However, the mechanism by which Dex mediates the progression of liver inj...
Citation: Journal of Inflammation 2021 18:20 -
AIM2 nuclear exit and inflammasome activation in chronic obstructive pulmonary disease and response to cigarette smoke
The role inflammasomes play in chronic obstructive pulmonary disease (COPD) is unclear. We hypothesised that the AIM2 inflammasome is activated in the airways of COPD patients, and in response to cigarette smoke.
Citation: Journal of Inflammation 2021 18:19 -
RETRACTED ARTICLE: VEGF as a potential molecular target in periodontitis: a meta-analysis and microarray data validation
Anti-vascular endothelial growth factor (VEGF) has been used as a therapeutic drug for the treatment of some human diseases. However, no systematic evidence is performed for assessing the role of VEGF in perio...
Citation: Journal of Inflammation 2021 18:18 -
Esomeprazole attenuates inflammatory and fibrotic response in lung cells through the MAPK/Nrf2/HO1 pathway
Idiopathic pulmonary fibrosis (IPF) is an orphan disease characterized by progressive loss of lung function resulting in shortness of breath and often death within 3–4 years of diagnosis. Repetitive lung injur...
Citation: Journal of Inflammation 2021 18:17 -
The impact of E-cigarette vaping and vapour constituents on bone health
In contrast to cigarettes, electronic cigarette use (E-cigarettes) has grown substantially over the last decade. This is due to their promotion as both a safer alternative to cigarettes and as an aide to stop ...
Citation: Journal of Inflammation 2021 18:16 -
Correction to: Research Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function
Citation: Journal of Inflammation 2021 18:15 -
Asthmatic condition induced the activity of exosome secretory pathway in rat pulmonary tissues
The recent studies highlighted the critical role of exosomes in the regulation of inflammation. Here, we investigated the dynamic biogenesis of the exosomes in the rat model of asthma.
Citation: Journal of Inflammation 2021 18:14 -
Interleukin 10 and interleukin 10 receptor in paediatric inflammatory bowel disease: from bench to bedside lesson
The differences between adults and children in inflammatory bowel disease (IBD) phenotype, severity, complications, co-morbidities, and response to the therapy resulted in the extraction of paediatric IBD. It ...
Citation: Journal of Inflammation 2021 18:13 -
LncRNA TUG1 regulates the development of ischemia-reperfusion mediated acute kidney injury through miR-494-3p/E-cadherin axis
Acute kidney injury (AKI) results from renal dysfunction caused by various causes, resulting in high mortality. The underlying mechanisms of ischemia-reperfusion (I/R) induced AKI is very complicated and neede...
Citation: Journal of Inflammation 2021 18:12 -
Pellino1 promoted inflammation in lung injury model of sepsis by TRAF6/ NF-κB signal pathway
This study was designed to investigate the role of Pellino1 in lung injury model of sepsis and its anti-inflammation mechanism.
Citation: Journal of Inflammation 2021 18:11 -
Effect of docosahexaenoic acid plus insulin on atherosclerotic human endothelial cells
Atherosclerosis is touted as one of the most critical consequences of diabetes mellitus indicated by local inflammation of endothelial cells. The Effect of Omega 3 fatty acids, mainly docosahexaenoic acid (DHA...
Citation: Journal of Inflammation 2021 18:10 -
Dendritic cells transduced with TIPE-2 recombinant adenovirus induces T cells suppression
TIPE-2 has been identified as a negative regulator of both innate and adaptive immunity and is involved in several inflammatory diseases. However, the role of immune suppression of dendritic cells (DCs) transd...
Citation: Journal of Inflammation 2021 18:9 -
MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway
Sepsis is a complex syndrome characterized by a dysregulated inflammatory response to systemic infection and leads to shock, multiple organ failure and death especially if not recognized early and treated prom...
Citation: Journal of Inflammation 2021 18:8 -
Overexpression of SP1 restores autophagy to alleviate acute renal injury induced by ischemia-reperfusion through the miR-205/PTEN/Akt pathway
Acute kidney injury (AKI) is a major kidney disease with poor clinical outcome. SP1, a well-known transcription factor, plays a critical role in AKI and subsequent kidney repair through the regulation of vario...
Citation: Journal of Inflammation 2021 18:7 -
RETRACTED ARTICLE: Impact of NF-κB pathway on the intervertebral disc inflammation and degeneration induced by over‐mechanical stretching stress
Intervertebral disk degeneration (IVDD) contributes to low back pain. Increased cell apoptosis and inflammation, decreased extracellular matrix are associated with IVDD. Nuclear factor-kappa B (NF-κB) signalin...
Citation: Journal of Inflammation 2021 18:6 -
Lactobacillus fermentum CQPC07 attenuates obesity, inflammation and dyslipidemia by modulating the antioxidant capacity and lipid metabolism in high-fat diet induced obese mice
Obesity is an epidemic disease in the world, the treatment and prevention of obesity methods have gained great attention. Lactobacillus is the main member of probiotics, and the physiological activity of it is...
Citation: Journal of Inflammation 2021 18:5 -
Role of melatonin in the angiogenesis potential; highlights on the cardiovascular disease
Melatonin possesses multi-organ and pleiotropic effects with potency to control angiogenesis at both molecular and cellular levels. To date, many efforts have been made to control and regulate the dynamic of a...
Citation: Journal of Inflammation 2021 18:4 -
Anti-inflammatory potential of Quercetin in COVID-19 treatment
SARS-CoV-2 is a betacoronavirus causing severe inflammatory pneumonia, so that excessive inflammation is considered a risk factor for the disease. According to reports, cytokine storm is strongly responsible f...
Citation: Journal of Inflammation 2021 18:3 -
Inflammatory M1-like macrophages polarized by NK-4 undergo enhanced phenotypic switching to an anti-inflammatory M2-like phenotype upon co-culture with apoptotic cells
NK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which ...
Citation: Journal of Inflammation 2021 18:2 -
Dexamethasone can attenuate the pulmonary inflammatory response via regulation of the lncH19/miR-324-3p cascade
To investigate lncRNAs and their roles in regulating the pulmonary inflammatory response under dexamethasone (Dex) treatment.
Citation: Journal of Inflammation 2021 18:1 -
Chronic intermittent hypobaric hypoxia improves markers of iron metabolism in a model of dietary-induced obesity
Obesity, a risk factor for many chronic diseases, is a potential independent risk factor for iron deficiency. Evidence has shown that chronic intermittent hypobaric hypoxia (CIHH) has protective or improved ef...
Citation: Journal of Inflammation 2020 17:36 -
PPARα and PPARβ/δ are negatively correlated with proinflammatory markers in leukocytes of an obese pediatric population
Obesity configures a pathophysiological profile that predisposes the development of metabolic and cardiovascular diseases, critically impacting public health. The chronic dysregulation of immuno-metabolic comp...
Citation: Journal of Inflammation 2020 17:35 -
Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury
Neutrophils rapidly respond to and clear infection from tissues, but can also induce tissue damage through excessive degranulation, when acute inflammation proceeds unchecked. A number of key neutrophil functi...
Citation: Journal of Inflammation 2020 17:34 -
Hypoxia: A key feature of COVID-19 launching activation of HIF-1 and cytokine storm
COVID-19, disease caused by the new coronavirus, SARS-CoV-2, appeared in the end of 2019 and was rapidly spread in most countries. This respiratory virus has different symptoms from moderate to severe, and res...
Citation: Journal of Inflammation 2020 17:33 -
Association of intestinal and systemic inflammatory biomarkers with immune reconstitution in HIV+ patients on ART
HIV infection is characterized by CD4+ T-cells depletion related to gut damage, microbial translocation, immune activation and intestinal and systemic low-grade inflammation. With the use of antiretroviral treatm...
Citation: Journal of Inflammation 2020 17:32 -
LncRNA THRIL is upregulated in sepsis and sponges miR-19a to upregulate TNF-α in human bronchial epithelial cells
Long non-coding RNAs (lncRNAs) have been demonstrated to play critical roles in various diseases. Our bioinformatics analysis showed that lncRNA TNFα and heterogenous nuclear ribonucleoprotein L (hnRNPL) relat...
Citation: Journal of Inflammation 2020 17:31 -
Compound amino acid combined with high-dose vitamin B6 attenuate traumatic coagulopathy via inhibiting inflammation by HMGB1/TLR4/NF-κB pathway
Traumatic coagulopathy (TC) arises primarily from coagulation system failure to maintain adequate hemostasis after serious blood loss or trauma. Circulatory homeostasis restoration is the mainstay of the thera...
Citation: Journal of Inflammation 2020 17:30 -
Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis
Inflammatory bowel disease (IBD) is the collective term for chronic immune-mediated diseases of unknown, multifactorial etiology, arising from the interplay between genetic and environmental factors and includ...
Citation: Journal of Inflammation 2020 17:29 -
Levels of mannose-binding lectin (MBL) associates with sepsis-related in-hospital mortality in women
Mannose-binding lectin (MBL) mediates the innate immune response either through direct opsonisation of microorganisms or through activation of the complement system. There are conflicting data whether MBL defi...
Citation: Journal of Inflammation 2020 17:28 -
Tissue alkaline phosphatase activity and expression in an experimental infant swine model of cardiopulmonary bypass with deep hypothermic circulatory arrest
Infant cardiac surgery with cardiopulmonary bypass results in decreased circulating alkaline phosphatase that is associated with poor postoperative outcomes. Bovine intestinal alkaline phosphatase infusion rep...
Citation: Journal of Inflammation 2020 17:27 -
Emodin alleviates LPS-induced inflammatory response in lung injury rat by affecting the function of granulocytes
Acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) are critical life-threatening syndromes characterized by the infiltration of a large number of granulocytes (mainly neutrophils) that l...
Citation: Journal of Inflammation 2020 17:26 -
N-acetylcysteine alleviates post-resuscitation myocardial dysfunction and improves survival outcomes via partly inhibiting NLRP3 inflammasome induced-pyroptosis
NOD-like receptor 3 (NLRP3) inflammasome is necessary to initiate acute sterile inflammation. Increasing evidence indicates the activation of NLRP3 inflammasome induced pyroptosis is closely related to reactiv...
Citation: Journal of Inflammation 2020 17:25 -
Offspring sex affects the susceptibility to maternal smoking-induced lung inflammation and the effect of maternal antioxidant supplementation in mice
Cigarette smoke exposure (SE) during pregnancy is the largest modifiable risk factor for the development of lung disorders in offspring. We have previously shown that maternal L-Carnitine treatment can reduce ...
Citation: Journal of Inflammation 2020 17:24 -
Potential interaction between lysophosphatidic acid and tumor-associated macrophages in ovarian carcinoma
Ovarian carcinoma is the deadliest type of gynecological cancer. The unique tumor microenvironment enables specific and efficient metastasis, weakens immunological monitoring, and mediates drug resistance. Tum...
Citation: Journal of Inflammation 2020 17:23 -
NLRP3 inflammasome inhibitor MCC950 attenuates primary dysmenorrhea in mice via the NF-κB/COX-2/PG pathway
Primary dysmenorrhea (PD) constitutes a common gynecological disease among young women. The NLRP3 inflammasome may be activated and expressed in PD, but the mechanistic link between NLRP3 inflammasome activati...
Citation: Journal of Inflammation 2020 17:22 -
SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping
The current pandemic of COVID-19 has caused severe morbidity and mortality across the globe. People with a smoking history have severe disease outcomes by COVID-19 infection. Epidemiological studies show that ...
Citation: Journal of Inflammation 2020 17:21 -
A novel sphingosylphosphorylcholine and sphingosine-1-phosphate receptor 1 antagonist, KRO-105714, for alleviating atopic dermatitis
Atopic dermatitis (eczema) is a type of inflammation of the skin, which presents with itchy, red, swollen, and cracked skin. The high global incidence of atopic dermatitis makes it one of the major skin diseas...
Citation: Journal of Inflammation 2020 17:20 -
Efficacy and safety of aerosol inhalation of recombinant human interferon α1b (IFNα1b) injection for noninfluenza viral pneumonia, a multicenter, randomized, double-blind, placebo-controlled trial
To investigate the efficacy and safety of aerosol inhalation of recombinant human interferon α1b (IFNα1b) injection for noninfluenza viral pneumonia.
Citation: Journal of Inflammation 2020 17:19 -
Inhibition of carrageenan-induced dental inflammatory responses owing to decreased TRPV1 activity by Dexmedetomidine
Dexmedetomidine (Dex) is a highly selective agonist of the α2 adrenergic receptor and a common sedative; however, its anti-inflammatory effect has been studied. In this study, the inhibitory effect of Dex on i...
Citation: Journal of Inflammation 2020 17:18 -
MiRNA-494 enhances M1 macrophage polarization via Nrdp1 in ICH mice model
Ubiquitination-mediated M1/M2 macrophage polarization plays important roles in the pathogenesis of immune disease. However, the regulatory mechanism of ubiquitination during M1/M2 macrophage polarization follo...
Citation: Journal of Inflammation 2020 17:17
Follow
Annual Journal Metrics
-
Citation Impact
Journal Impact Factor: 4.4 (2023)
5-year Journal Impact Factor: 4.6 (2023)
Source Normalized Impact per Paper (SNIP): 0.881 (2024)
SCImago Journal Rank (SJR): 1.214 (2024)Speed
Submission to first editorial decision (median days): 18
Submission to acceptance (median days): 199Usage 2024
Downloads: 416,662
Altmetric mentions: 166