Fig. 6
From: Contribution of brain pericytes to neuroinflammation following repetitive head trauma

PDGF-BB stimulation can prevent or mitigate the activated immune-response of pericytes upon exposure to pro-inflammatory molecules. Pericytes were treated with cytokines and/or vehicle for 24 h and PDGF-BB stimulation was given prior or following the inflammatory insult. Cells were fixed and immunostained for A VCAM1, B STAT1, C pAkt, and D NFkB. E Cell lysates were analyzed by a total MMP9 ELISA assay. F Representative images for each treatment group with DAPI (blue) are shown. All results are presented as mean ± SEM. *p < 0.05; **p < 0.01; *** p < 0.001; ****p < 0.0001 Multiple comparisons (ANOVA). Scale bar 40 μm