Fig. 2

IL-33 in allergic diseases pathology. IL-33 produce by different cell such as epithelial cells and bind to its receptor, then activates various ST2 + immune cell types implicated in the allergic responses for example, Th2, ILC, Mast cell. These cells produce cytokine such as IL-4, IL-5 and IL-13, that impact on EOS for mediator releases. Innate lymphoid cells (ILC2s); Eosinophil (EOS)