Fig. 5
From: Alpha-1 antitrypsin reduces inflammation and vasculopathy in mice with oxygen-induced retinopathy
AAT reduced vascular pathology in retina of OIR mice at P18 and P12. Con, control. HSA, human serum albumin. AAT, alpha-1 antitrypsin. A. Representative images of retinal flatmounts stained with FITC-isolectin to show blood vessels (green). Top panels show whole retina. A quadrant of retina (yellow box) is magnified in the lower panel. Asterisks denote vaso-obliteration. Arrowheads denote neovascularisation. Scale bar, 500 μm. B. Quantitation of vaso-obliteration at P18. C. Quantitation of neovascularisation at P18. D. Quantitation of vaso-obliteration at P12. n = 7 to 15 mice from 2 to 3 litters of mice per group. ***p < 0.001, and ****p < 0.0001. Data were analysed using one-way ANOVA followed by Tukey’s test or Welch’s ANOVA followed by Dunnett’s T3 test, or unpaired t test. Values are mean ± SEM