Fig. 3
From: Basement membranes’ role in immune cell recruitment to the central nervous system
Simplified diagram showing the process of neutrophil vessel extravasation, split into four panels: Tethering, Rolling, Adhesion and Extravasation. During neutrophil tethering, endothelial CD62 interacts with CD62P and PSGL1 establishing a transient contact. In rolling, LFA-1 and ICAM-2 react in trans and allow neutrophils to roll. In adhesion, endothelial-cell derived chemokines induce the expression of beta-2 integrin, which induces neutrophil adhesion/arrest. Finally, neutrophils ‘crawl’ along blood vessels in a MAC-1 dependent manner and use their leading-edge uropod to extravasate out of blood vessels. Illustrations of the following cells are shown: astrocytes in purple, microglia in yellow and activated microglia in red