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Fig. 2 | Journal of Inflammation

Fig. 2

From: TRPV4 modulates inflammatory responses and apoptosis in enteric glial cells triggered by Clostridioides difficile toxins A and B

Fig. 2

C. difficile infection (CDI) increases the expression of TRPV4 in the cecum and colon of infected mice. A) Photomicrographs showing the immunohistochemical staining for TRPV4 within the intestinal regions (cecum and colon) of uninfected mice and those subjected to CDI. In the control group (uninfected animals), TRPV4 is constitutively expressed in the mucosa immune cells (orange arrow) and myenteric plexus (red arrow); in animals exposed to C. difficile, a pronounced increase in immunostaining is observed in the cecum and colon, particularly in immune cells (yellow arrows) and in the myenteric plexus (red arrow), clearly observed at 400x magnification (Scale bar = 20 μm.). The standard images were taken at 100x magnification (Scale bar = 50 μm. B) The graph represents the mean ± SEM of the number of immunopositive cells for TRPV4 in the cecum and colon of mice subjected to CDI (infected group) and non-infected (control group). Statistical analysis was conducted using the student’s t-test was used. ***p < 0.0001

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Journal of Inflammation

ISSN: 1476-9255

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