Fig. 3
From: Non-ionic surfactant vesicles exert anti-inflammatory effects through inhibition of NFκB
NISV treatment downregulates transcripts induced by LPS stimulation. Transcriptomic analysis was performed on RNA extracted from BMDM stimulated with LPS and treated with 1.5 mM NISV, and BMDM controls untreated with NISV, and unstimulated with LPS. A Shows the effects of NISV on the genes responsible for chemokine, interleukin and TNF production in LPS-stimulated BMDM. B shows gene expression involved in LPS signal transduction by the TLR4 signalling cascade as they are altered by NISV treatment in LPS-stimulated cells. Heat maps were made using Prism 8. * Indicates significant change. (p < 0.05)