Fig. 4

LPS administration led to morphological changes of IBA1-positive cells from a ramified to an ameboid morphology. A Representative image of IBA1-positive cells in the motor cortex. B Number of IBA1-positive cells in the motor cortex. Each dot represents one animal (n=4). C Cell area of IBA-1 positive cells in the motor cortex. Each dot represents one cell (n>100 cells per animal, n=4 animals per group). D Ramification index of IBA-1 positive cells in the motor cortex. Each dot represents one cell (n>100 cells per animal, n=4 animals per group) (E) Representative image of IBA1-positive cells in the striatum. F Number of IBA1-positive cells in the striatum. Each dot represents one animal (n=4). G Cell area of IBA-1 positive cells in the striatum. Each dot represents one cell (n>100 cells per animal, n=4 animals per group) (H) Ramification index of IBA-1 positive cells in the striatum. Each dot represents one cell (n>100 cells per animal, n=4 animals per group). The average cell area and ramification index per animal were calculated and are shown in Supplementary Figure 2. Statistical differences in cell number, cell area, and ramification index were calculated as the average of 4 animals per group, as shown in Supplementary Figure 2. Statistical differences are shown as ***p<0.001, **p<0.01, *p<0.05, and ns- not significant