Fig. 1

LPS administration results in a marked increase in sickness behavior (A) Illustration of the experimental design indicating the behavior tests performed and blood collections at 8h and 24h after LPS or saline administration. H.C. – Home cage monitoring; O.F. – Open Field; I.O. – Introduced Object; Y.M. – Y-Maze; M.W. – MouseWalker; Rot – Rotarod. B Animal body weight before and 24h after LPS administration in saline and LPS groups (n=19). C Food intake normalized by body weight (n=9 cages - 2 animals per cage). D Glucose levels (n=11). E Home cage monitoring system used, relying on a camera on a tripod recording the home cage (n=12). F Time moving in the home cage (n=12). G Number of eating interactions (n=12). Statistical changes are shown as ns - not statistically significant, *p<0.05, ** p<0.01, and *** p<0.001