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Fig. 4 | Journal of Inflammation

Fig. 4

From: Sonic Hedgehog reduces inflammatory response, decreases blood-spinal cord barrier permeability, and improves locomotor function recovery in an acute spinal cord injury rat model

Fig. 4

(A) Shh-treated animals (n = 5) demonstrated improved locomotor function, as indicated by significantly higher BBB scores at 7 days post-injury (dpi) compared to untreated control animals (p < 0.001, n = 6). (B) In the Gridwalk test, both the Shh- and the control group showed a similar rate of stepping errors at 3 dpi and 7 dpi (for both timepoints: Shh: n = 5, Control: n = 6). Experiments were conducted in triplicate, with data interpreted by two blinded observers and averaged. Data are expressed as BBB points or stepping errors and presented as mean ± SEM. Statistical analysis was performed using two-way ANOVA with post hoc Tukey-HSD tests (***p < 0.001)

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Journal of Inflammation

ISSN: 1476-9255

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