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Fig. 6 | Journal of Inflammation

Fig. 6

From: Histone H3 posttranslational modified enzymes defined neutrophil plasticity and their vulnerability to IL-10 in the course of the inflammation

Fig. 6

A Gene Ontology analysis of neutrophils isolated from NMOSD, sepsis and periodontitis patients confirmed that H3K4me3 positions target genes within the main processes associated with chromatin organisation. NMOSD neutrophils are characterised by positioning target genes related to histone acetyltransferase activity that corresponds with TNF-preactivated neutrophils (blue arrows), sepsis neutrophils positioned target genes associated with histone methyltransferase, especially H3K4 specific what correspond with LPS-stimulated neutrophils (red arrows). In turn, periodontitis neutrophils positioned target genes within the term ‘Histone demethylase activity’, particularly H3K9 (green arrows), which correlates with IL-10-stimulated neutrophils. B Binding site overlap in the GO terms ‘Chromatin organisation’, ‘Histone H3K4 trimethylation’ and ‘Histone demethylase activity H3K9 specific’. C The comparison of peak density within PTM enzymes revealed high signal within TSSs (Exon 1) of MLL1 and SETD1A in sepsis circulating neutrophils, high density within CHD1 as well as JMJD2A in periodontitis and sepsis which reflects in vitro model of IL-10-stimulated, but not in LPS-stimulated neutrophils

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Journal of Inflammation

ISSN: 1476-9255

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