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Fig. 5 | Journal of Inflammation

Fig. 5

From: Histone H3 posttranslational modified enzymes defined neutrophil plasticity and their vulnerability to IL-10 in the course of the inflammation

Fig. 5

A Circulating sepsis neutrophils, similar to the in vitro LPS model, induced inflammation characterised by high expression of SETD1A and MLL1 and their colocalisation to the nucleus. B In turn, periodontitis neutrophils, similar to the in vitro IL-10 model, stimulated HC neutrophils with high expression of JMJD2A and CHD1 (A and B upper panels). The example of ICC analysis and confocal 3D projection confirmed colocalisation of SETD1A and MLL1 within the nucleus in sepsis patients, while colocalisation of JMJD2A and CHD1 within the nucleus mainly in periodontitis patients (white arrows) (A and B right panels). Data are presented as mean ± SD calculated based on 3 cases of patients with NMOSD, 6 with sepsis and 12 with periodontitis

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Journal of Inflammation

ISSN: 1476-9255

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