Fig. 1

Effects of TFPI2 knockdown on cardiac remodeling and function recovery after MI

(a, b) Western blot analysis and immunohistochemical staining of TFPI2 in the myocardium of mice at 3 weeks after MI (n = 3). (c, d) Western blot analysis and TFPI2 staining to verify TFPI2 knockdown. (e) Images of the infarct and border zones after Masson’s trichome staining of the myocardial samples at 3 weeks after infarction, and quantitative analysis of the fibrosis area (n = 3). (f) Quantitative analysis of function recovery using echocardiography (n = 4). Sham, sham operation (magnification: ×100); MI, myocardial infarction; DM, diabetes mellitus; sh-TFPI2, sh-TFPI2 transfection; sh-NC, sh-NC transfection. Data represent mean ± standard deviation (SD). Data were analyzed using one-way ANOVA and Tukey’s post hoc test. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001