Fig. 5

Impact on selected acute inflammatory processes and phenotypes in Tr14 vs. saline control (A, C, and E); and diclofenac vs. placebo control (B, D, and F). A-D The processes and phenotype levels were normalized between + 1 (upregulation; red color) and -1 (downregulation; blue color). Acute inflammatory processes and phenotypes were grouped into 4 phases (inflammation initiation, transition, resolution, and homeostasis). Circles from inner to outer regions represent treatment time points 12 h, 24 h, 36 h, 72 h, 96 h, 120 h, and 192 h. E–F For each process at a given time point and treatment, network- and expression-based motif ranking creates a central regulatory network (CRN) representing the molecular interaction associated with the selected phenotype element (e.g., M2 Phenotype and Behavior). The CRN highlights the up-regulated (red) or down-regulated (blue) differentially expressed genes (padj < 0.05) in the sample