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Fig. 6 | Journal of Inflammation

Fig. 6

From: 5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages

Fig. 6

Protective effect of 5-methoxyflavone on LPS-induced ALI in mice. (A) Lung pathological changes of LPS-challenged mice with or without 5-methoxyflavone administration (i.g., 25, 50 mg⋅kg-1⋅d-1) were examined by H&E staining. (B) The lung injury score of all groups was assessed based on lung pathological changes. (C) Lung/body weight ratios (lung index; an indicator of lung injury) of all groups were measured at 48 h after LPS challenge. (D) Representative images of active-caspase 3 and TUNEL-positive cells in the epithelial (EpCAM+) cells of the lung tissues were presented. (E) The fluorescence intensities for active-caspase 3 and TUNEL in the epithelial (EpCAM+) cells were quantified. (F) Immunofluorescence staining was performed to assess the expression of Bax and Bcl2 in the epithelial (EpCAM+) cells of the lung tissues. (G) The fluorescence intensities for Bax and Bcl2 in the epithelial (EpCAM+) cells were quantified. (H) Survival curves for LPS-challenged mice with or without 5-methoxyflavone administration (n = 12 for each group). ###P < 0.01 versus the control group; *P < 0.05, **P < 0.01, ***P < 0.001 versus the LPS group

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Journal of Inflammation

ISSN: 1476-9255

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