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Fig. 3 | Journal of Inflammation

Fig. 3

From: Influenza a virus triggers acute exacerbation of chronic obstructive pulmonary disease by increasing proinflammatory cytokines secretion via NLRP3 inflammasome activation

Fig. 3

Specific siRNA downregulating NLRP3 inflammasome pathway in DHBE. DHBE cells were pre-transfected with 40 nM siNLRP3 or siNC for 24 h and 48 h for detecting the level of mRNA and protein, respectively, following infected with IAV(MOI = 2) for 3 h. NLRP3 inflammasome components were detected by qRT-PCR.: the levels of A NLRP3, B ASC, C Caspase-1, D IL-1β, E IL-18 F NLRP3 inflammasome components were detected by immunoblot: G normalized ratio of NLRP3 inflammation signaling pathway to β-actin. (*denote P < 0.05, **denotes P < 0.01, ***denotes P < 0.001, significant difference between siNC and siNLRP3-1; #denote P < 0.05, ##denotes P < 0.01, ###denotes P < 0.001, significant difference between siNC and siNLRP3-2). Data are presented as the mean ± SD of three independent experiments

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Journal of Inflammation

ISSN: 1476-9255

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