Fig. 4

Inhibition of IL-1β levels by SAGE in human macrophages. Macrophages (1 × 106 cells/well) were cultured in serum-free media (37 °C, 5% CO2/95%O2 18 h) with LPS (50 ng/mL), SAGE, or vehicle alone. Conditioned medium were analyzed for IL-1β by ELISA. Each value represents the mean of 3 cultures ± the standard error of the mean (S.E.M.). #: p < 0.05 vs normal and *: P < 0.05 vs LPS