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Fig. 1 | Journal of Inflammation

Fig. 1

From: MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway

Fig. 1

MAR1 inhibited the inflammatory response of RAW264.7 cells and hPBMCs induced by LPS in a dose-dependent manner. RAW264.7 cells and hPBMCs were pretreated with different concentrations (0.1 nM, 1 nM, 10 nM and 100 nM) of MAR1 for 12 h and then exposed to LPS (10 µg/mL) for 12 h. a, TNF-α, IL-1β and IL-6 expression were detected by RT-qPCR; b, TNF-α, IL-1β and IL-6 secretion were measured using ELISA. c, The protein levels of SIRT1, PGC-1α and PPAR-γ were evaluated by Western blot. Data were shown as the means ± SD. Each experiment was repeated in triplicate. *p < 0.05, **p < 0.01, ***p < 0.001

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Journal of Inflammation

ISSN: 1476-9255

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