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Table 2 Meta-analysis of the association between IL-10 polymorphisms and BD risk

From: Exploring the association of IL-10 polymorphisms in Behcet’s disease: a systematic review and meta-analysis

polymorphism

No. of studies

Comparison

Test of association

Test of heterogeneity

Egger’s test (P)

Metareg’s test (P)

OR (95% CI)

P-value

P- value

I2 (%)

Q test

rs1800896 A/G

10

GG vs. AA

0.925 (0.684–1.251)

0.613

0.266

19.9

9.98

0.746

0.689

GG + GA vs. AA

0.936 (0.733–1.195)

0.596

0.020

56/0

18.20

0.836

0.866

GG vs. GA + AA

0.975 (0.660–1.441)

0.900

0.025

54.4

17.55

0.619

0.640

AG vs. AA

0.945 (0.717–1.245)

0.687

0.007

62.2

21.17

0.822

0.870

G vs. A

0.965 (0.831–1.120)

0.640

0.084

41.0

15.25

0.816

0.807

rs1800871 T/C

19

CC vs. TT

0.466 (0.368–0.589)

0.000

0.003

57.4

32.88

0.081

0.347

CC + CT vs. TT

0.692 (0.584–0.820)

0.000

0.000

66.1

41.33

0.842

0.674

CC vs. CT + TT

0.557 (0.405–0.767)

0.000

0.000

86.6

119.02

0.032

0.123

CT vs. TT

0.842 (0.572–1.240)

0.384

0.000

93.7

220.52

0.542

0.883

C vs. T

0.691 (0.626–0.762)

0.000

0.000

67.8

49.73

0.363

0.493

rs1800872 A/C

13

CC vs. AA

0.723 (0.440–1.186)

0.199

0.000

72.4

32.63

0.161

0.360

CC + CA vs. AA

0.713 (0.535–0.951)

0.021

0.004

62.4

23.94

0.116

0.276

CC vs. CA + AA

0.776 (0.583–1.032)

0.082

0.004

60.3

27.71

0.210

0.367

CA vs. AA

0.716 (0.546–0.940)

0.016

0.024

53.0

19.13

0.101

0.313

C vs. A

0.779 (0.662–0.915)

0.002

0.000

70.2

33.59

0.194

0.423

rs1518111 A/G

13

GG vs. AA

0.570 (0.471–0.690)

0.000

0.459

0.0

1.56

0.622

0.741

GG + GA vs. AA

0.697)0.596–0.814)

0.000

0.393

0.0

1.87

0.684

0.533

GG vs. GA + AA

0.701 (0.623–0.790)

0.000

0.505

0.0

3.32

0.558

0.967

AG vs. AA

0.786 (0.667–0.927)

0.004

0.723

0.0

0.65

0.604

0.645

G vs. A

0.738 (0.681–0.800)

0.000

0.106

36.7

15.79

0.500

0.352

rs1554286 T/C

3

CC vs. TT

0.508 (0.372–0.694)

0.000

0.198

38.2

3.23

0.795

0.868

CC + CT vs. TT

0.605)0.467–0.785(

0.000

0.087

59.1

4.89

0.626

0.466

CC vs. CT + TT

0.665)0.484–0.916(

0.012

0.041

68.7

6.40

0.487

0.893

CT vs. TT

0.646 (0.502–0.832)

0.001

0.115

53.8

4.33

0.656

0.506

C vs. T

0.582 (0.440–0.770)

0.000

0.000

87.7

16.23

0.384

0.265

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Journal of Inflammation

ISSN: 1476-9255

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