Fig. 1

Effect of IL-35 on inflammation in a rat model of DNP. The fasting insulin concentration using ELISA assay (a), Changes in MWT and TWL (b) in baseline, after 14 days of intraperitoneal injection with STZ and after administrating different drugs for 1, 3, 7 and 14 days and serum levels of IL-35 (c), IL-1β (d), IL-6 (e) and TNF-α (f) and IL-10 (g) in the groups of Control, DNP, DNP + vehicle, SP, IL-35 and IL-35 + Ani. *P < 0.05 vs. the control group; #P < 0.05 vs. the DNP + vehicle group; $P < 0.05 vs. the IL-35 group. n = 6 per group