Figure 1

Relative levels of transcripts encoding enzymes in the kynurenine pathway in human skin-derived fibroblasts from 7 individuals. Transcripts encoding the following enzymes were investigated; Indoleamine 2,3-dioxygenase 1 (IDO1), Tryptophan 2,3-dioxygenase (TDO), Kynurenine aminotransferases (KAT) 1-4, Kynurenine 3-monooxygenase (KMO), Kynureninase (KYNU), 3-Hydroxyanthranilic acid oxygenase (HAAO) and Quinolinic acid phosphoribosyltransferase (QPRT).