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Table 2 Distribution of alleles and gene polymorphisms in CKD patients and in controls

From: Genetic polymorphism of ACE and the angiotensin II type1 receptor genes in children with chronic kidney disease

Gene

CT

(n = 32)

MHD

(n = 44)

Controls

(n = 70)

Significance

ACE Alleles

I

24 (37.5%)

20(22.73%)

97 (69.29%)

*For D allele MHD

Carriers:

OR = 0.13,

95% CI (0.07-0.24)

X2 = 46.89,

P = 0.0001

 

D

40(62.5%)

68 (77.27%)*

43 (30.71%)

 

ACE genotypes

II

4(12.5%)

1(2.27%)

38(54.29%)

* OR = 0.012,

95% CI

(0.001-0.095)

X2 = 36.97, P = 0.0001

 

ID

16(50%)

18(40.91%)

21 (30%)

 
 

DD

12(37.5%)

25(56.82%)*

11 (15.71%)

 

AT1R Alleles

A

40(62.5%)

52(59.09%)

114 (81.42%)

*For C allele MHD

Carriers:

OR = 0.33

95%CI(0.18-0.60)

X2 = 13.61,

P = 0.0001

 

C

24(37.5%)

36(40.91%)*

26 (18.58%)

 

AT1R genotypes

AA

12 (37.5%)

16(36.37%)

48(68.57%)

*OR = 0.23,95%CI

(0.10-0.51)

X2 = 13.63, P = 0.0001

 

AC

16 (50%)

20 (45.45%)

18 (25.72%)

 
 

CC

4(12.5%)

8 (18.18%)*

4(5.71%)

 
  1. Data was evaluated by the gene counting method. Test for allele frequency difference Chi-square tests were used. Values were presented as percentage. CT = conservative treatment, MHD = maintenance hemodialysis, ACE = angiotensin converting enzyme, AT1R = angiotensin II type 1 receptor.
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Journal of Inflammation

ISSN: 1476-9255

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