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Figure 2 | Journal of Inflammation

Figure 2

From: Suppression of LPS-induced matrix-metalloproteinase responses in macrophages exposed to phenytoin and its metabolite,5-(p-hydroxyphenyl-), 5-phenylhydantoin

Figure 2

The effect of phenytoin, HPPH and LPS on levels of tissue inhibitor of matrix metalloproteinase-1 in conditioned medium from macrophage cultures. Primary human monocyte-derived macrophages (n = 6 independent cultures) were pretreated with phenytoin or HPPH (15 μg/mL and 50 μg/mL) for 1 hour prior to challenge with 100 ng/mL A. actinomycetemcomitans LPS and the levels of tissue inhibitor of matrix metalloproteinase-1 measured after 24 hours in conditioned media by multiplex analysis. TIMP-1, tissue inhibitor of matrix metalloproteinase-1; CON, control; PHT, phenytoin; HPPH, 5-(4-hydroxyphenyl-),5-phenylhydantoin; LPS, lipopolysaccharide. Compared to CON, # p < 0.05, ## p < 0.01, ### p < 0.001, compared to LPS, * p < 0.05, ** p < 0.01, *** p < 0.001. Student t-test, n = 6 independent donors.

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Journal of Inflammation

ISSN: 1476-9255

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