Figure 4
IL-8/CXCL8-elicited gIVaPLA 2 enzyme activity. PMNs were pretreated with either 3 μM - 30 μm arachidonyl trifluoromethylketone (TFMK) or pyrrophenone for 30 min prior to IL-8/CXCL8 activation. Cytosolic gIVaPLA2 activity was expressed as picomole (pmol) arachidonic acid (AA)/30 min/106 cells [31]. Results are the mean ± SEM from N = 5 donor isolations. *P < 0.05 vs IL-8/CXCL8-activated PMNs; **P < 0.01 vs IL-8/CXCL8 -activated PMNs.