Figure 1

Administration of CCL2 in vivo leads to a selective increase in circulating monocytes. BALB/c mice were injected with 300 ng CCL2 or PBS i.v. into the tail vein. 30 min later, blood was collected and analyzed for white blood cell counts using an ADVIA system to quantify (A) total leukocytes, (B) lymphocytes, (C) monocytes, (D) neutrophils, (E) basophils and (F) eosinophils. ***p < 0.001 compared to PBS group. The data presented are the mean ± S.E.M. of six mice per group and are representative of three independent experiments.