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Table 2 LPS/IFN-γ driven macrophage expression of CD40 and CD86 is modulated by IL-12p40 siRNA.

From: Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo

Treatment

Mean Fluorescent Intensity (+/-SEM)

LPS/IFN-γ

siRNA

CD40

CD86

CD80

CD14

MHCII

-

-

22 (5)

9 (4)

34 (8)

44 (11)

19 (8)

-

IL-12p40

16 (9)

14 (1)

29 (2)

49 (4)

18 (8)

+

-

290 (27)

41(5)

102 (21)

86 (11)

46 (5)

+

IL-12p40

94 (17)*

7 (1)*

66 (13)

47 (9)

46 (5)

+

Mut.siRNA

241 (18)

72 (6)

102 (4)

86 (16)

43 (5)

  1. Data are the mean ± SEM to nearest whole number of MFI of 3 independent experiments, each performed in triplicate (n = 3), * statistical significance (α = 0.05) compared to cells stimulated with LPS/IFN-γ in the absence of IL-12p40 siRNA.
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Journal of Inflammation

ISSN: 1476-9255

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