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Figure 2 | Journal of Inflammation

Figure 2

From: Cancer, inflammation and the AT1 and AT2 receptors

Figure 2

AT1 signalling. Activation of AT1 has a powerful pro-inflammatory effect, promoting the expression of many pro-inflammatory mediators, such as cytokines, chemokines and adhesion molecules through the activation of signalling pathways. The influx, proliferation and behaviour of immune cells are steered away from an effective immune response to pathogens (thereby achieving immunosuppression) but instead towards activities consistent with a wound environment.

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Journal of Inflammation

ISSN: 1476-9255

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